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Target
Sulfide:quinone oxidoreductase, mitochondrial
Ligand
BDBM50579947
Substrate
n/a
Meas. Tech.
ChEMBL_2145890 (CHEMBL5030170)
IC50
121±n/a nM
Citation
 Baugh, SDP; Jackson, MR; Rashad, AA; Reitz, AB; Lam, PYS; Jorns, MS Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett 54:0 (2021) [PubMed]  Article 
Target
Name:
Sulfide:quinone oxidoreductase, mitochondrial
Synonyms:
1.8.5.8 | SQOR | SQOR_HUMAN | SQRDL
Type:
PROTEIN
Mol. Mass.:
49975.74
Organism:
Homo sapiens
Description:
ChEMBL_119262
Residue:
450
Sequence:
MVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVILAEFDYKAEPLETFPFDQSKERLSMYLMKADLMPFLYWNMMLRGYWGGPAFLRKLFHLGMS
  
Inhibitor
Name:
BDBM50579947
Synonyms:
CHEMBL5089512
Type:
Small organic molecule
Emp. Form.:
C19H15N3O
Mol. Mass.:
301.3419
SMILES:
CCOc1nc(nc(-c2ccccc2)c1C#N)-c1ccccc1
Structure:
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