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Target
Protein arginine N-methyltransferase 3
Ligand
BDBM178103
Substrate
n/a
Meas. Tech.
ChEMBL_2146489 (CHEMBL5030835)
IC50
4.0±n/a nM
Citation
 Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Chau, I; Eram, MS; Dela Seña, C; Park, KS; Meng, F; Chen, H; Zeng, H; Dong, A; Wu, H; Trush, VV; McLeod, D; Zepeda-Velázquez, CA; Campbell, RM; Mader, MM; Watson, BM; Schapira, M; Arrowsmith, CH; Al-Awar, R; Barsyte-Lovejoy, D; Kaniskan, HÜ; Brown, PJ; Vedadi, M; Jin, J A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J Med Chem 64:3697-3706 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3
Synonyms:
2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Type:
PROTEIN
Mol. Mass.:
59886.87
Organism:
Homo sapiens
Description:
ChEMBL_101368
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM178103
Synonyms:
MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C17H25N3O
Mol. Mass.:
287.3999
SMILES:
CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN
Structure:
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