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Target
Heparanase
Ligand
BDBM50147544
Substrate
n/a
Meas. Tech.
ChEBML_83907
IC50
400±n/a nM
Citation
 Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Porter, DW; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Stubberfield, CR; Turner, PR 2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors. Bioorg Med Chem Lett 14:3269-73 (2004) [PubMed]  Article 
Target
Name:
Heparanase
Synonyms:
Heparanase-1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE1 | HSE1 | HPSE_HUMAN | HPSE
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Human
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
  
Inhibitor
Name:
BDBM50147544
Synonyms:
2-(2-methoxy-5-(5-(4-(trifluoromethoxy)phenyl)benzo[d]oxazol-2-yl)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid | 2-{2-Methoxy-5-[5-(4-trifluoromethoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acid | CHEMBL112849
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc(cc1N1C(=O)c2ccc(cc2C1=O)C(O)=O)-c1nc2cc(ccc2o1)-c1ccc(OC(F)(F)F)cc1
Structure:
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