Reaction Details Report a problem with these data
Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50580105
Substrate
n/a
Meas. Tech.
ChEMBL_2147045 (CHEMBL5031391)
EC50
26330±n/a nM
Citation
 Nguyen, P; Doan, P; Rimpilainen, T; Konda Mani, S; Murugesan, A; Yli-Harja, O; Candeias, NR; Kandhavelu, M Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment. J Med Chem 64:10908-10918 (2021) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50580105
Synonyms:
CHEMBL5086989
Type:
Small organic molecule
Emp. Form.:
C13H10Cl2O4
Mol. Mass.:
301.122
SMILES:
OC(=O)CCC1=C(Cc2cc(Cl)cc(Cl)c12)C(O)=O |t:5|
Structure:
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