Reaction Details Report a problem with these data
Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50580104
Substrate
n/a
Meas. Tech.
ChEMBL_2147045 (CHEMBL5031391)
EC50
7670±n/a nM
Citation
 Nguyen, P; Doan, P; Rimpilainen, T; Konda Mani, S; Murugesan, A; Yli-Harja, O; Candeias, NR; Kandhavelu, M Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment. J Med Chem 64:10908-10918 (2021) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
GPR17 | GPR17_HUMAN
Type:
PROTEIN
Mol. Mass.:
41013.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1353471
Residue:
367
Sequence:
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
  
Inhibitor
Name:
BDBM50580104
Synonyms:
CHEMBL5083629
Type:
Small organic molecule
Emp. Form.:
C35H27ClFN3O5
Mol. Mass.:
624.057
SMILES:
Oc1c(Cl)cccc1C(N1CCc2c1cc(OC(=O)Nc1ccccc1)cc2OC(=O)Nc1ccccc1)c1ccc(F)cc1
Structure:
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