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Target
Nuclear receptor subfamily 2 group E member 1
Ligand
BDBM50580566
Substrate
n/a
Meas. Tech.
ChEMBL_2148634 (CHEMBL5033032)
EC50
67000±n/a nM
Citation
 Faudone, G; Bischoff-Kont, I; Rachor, L; Willems, S; Zhubi, R; Kaiser, A; Chaikuad, A; Knapp, S; Fürst, R; Heering, J; Merk, D Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. J Med Chem 64:8727-8738 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 2 group E member 1
Synonyms:
NR2E1 | NR2E1_HUMAN | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll
Type:
PROTEIN
Mol. Mass.:
42606.25
Organism:
Homo sapiens
Description:
ChEMBL_104473
Residue:
385
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
  
Inhibitor
Name:
BDBM50580566
Synonyms:
CHEMBL3304960
Type:
Small organic molecule
Emp. Form.:
C12H14N2
Mol. Mass.:
186.253
SMILES:
NC1CCc2[nH]c3ccccc3c2C1
Structure:
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