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Target
Nuclear receptor subfamily 2 group E member 1
Ligand
BDBM60973
Substrate
n/a
Meas. Tech.
ChEMBL_2148634 (CHEMBL5033032)
EC50
40000±n/a nM
Citation
 Faudone, G; Bischoff-Kont, I; Rachor, L; Willems, S; Zhubi, R; Kaiser, A; Chaikuad, A; Knapp, S; Fürst, R; Heering, J; Merk, D Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. J Med Chem 64:8727-8738 (2021) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 2 group E member 1
Synonyms:
NR2E1 | NR2E1_HUMAN | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll
Type:
PROTEIN
Mol. Mass.:
42606.25
Organism:
Homo sapiens
Description:
ChEMBL_104473
Residue:
385
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
  
Inhibitor
Name:
BDBM60973
Synonyms:
(2R)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol;hydrochloride | (2R)-1-(isopropylamino)-3-(1-naphthoxy)propan-2-ol;hydrochloride | (2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride | (R)-(+)-Propranolol hydrochloride | MLS001333595 | SMR000875288 | cid_66366
Type:
Small organic molecule
Emp. Form.:
C16H21NO2
Mol. Mass.:
259.3434
SMILES:
CC(C)NC[C@@H](O)COc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: