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Target
C-type lectin domain family 4 member M
Ligand
BDBM50580861
Substrate
n/a
Meas. Tech.
ChEMBL_2149165 (CHEMBL760181)
IC50
218±n/a nM
Citation
 Chakroun, K; Taouai, M; Porkolab, V; Luczkowiak, J; Sommer, R; Cheneau, C; Mathiron, D; Ben Maaouia, MA; Pilard, S; Abidi, R; Mullié, C; Fieschi, F; Cragg, PJ; Halary, F; Delgado, R; Benazza, M Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN. J Med Chem 64:14332-14343 (2021) [PubMed]  Article  BDB Entry
Target
Name:
C-type lectin domain family 4 member M
Synonyms:
CD209 antigen-like protein 1 | CD209L | CD209L1 | CD299 | CD_antigen=CD299 | CLEC4M | DC-SIGN-related protein | DC-SIGN2 | DC-SIGNR | Dendritic cell-specific ICAM-3-grabbing non-integrin 2 | L-SIGN | Liver/lymph node-specific ICAM-3-grabbing non-integrin
Type:
PROTEIN
Mol. Mass.:
45339.05
Organism:
Homo sapiens
Description:
ChEMBL_105433
Residue:
399
Sequence:
MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVSKVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAEFSGSGWNDNRCDVDNYWICKKPAACFRDE
  
Inhibitor
Name:
BDBM50580861
Synonyms:
CHEMBL5079779
Type:
Small organic molecule
Emp. Form.:
C148H216N32O40
Mol. Mass.:
3083.489
SMILES:
COC(=O)CNC(=O)CN(Cc1cn(CCCOc2c3Cc4cc(cc(Cc5cc(cc(Cc6cc(cc(Cc2cc(c3)C(C)(C)C)c6OCCCn2cc(CN(CC(=O)NCC(=O)OC)C(=O)CCCCCn3cc(CO[C@@H]6O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]6O)nn3)nn2)C(C)(C)C)c5OCCCn2cc(CN(CC(=O)NCC(=O)OC)C(=O)CCCCCn3cc(CO[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]5O)nn3)nn2)C(C)(C)C)c4OCCCn2cc(CN(CC(=O)NCC(=O)OC)C(=O)CCCCCn3cc(CO[C@@H]4O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]4O)nn3)nn2)C(C)(C)C)nn1)C(=O)CCCCCn1cc(CO[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]2O)nn1 |r|
Structure:
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