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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM50581591
Substrate
n/a
Meas. Tech.
ChEMBL_2151709 (CHEMBL5036171)
Kd
170±n/a nM
Citation
 Klein, VG; Bond, AG; Craigon, C; Lokey, RS; Ciulli, A Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem 64:18082-18101 (2021) [PubMed]  Article 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | Von Hippel-Lindau disease tumor suppressor | pVHL | VHL_HUMAN | VHL | Von Hippel-Lindau disease tumor suppressor protein (VBC)
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Human
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM50581591
Synonyms:
CHEMBL5087530
Type:
Small organic molecule
Emp. Form.:
C35H45N5O6S
Mol. Mass.:
663.84
SMILES:
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCNC(=O)Cc2ccccc2)C(C)(C)C)cc1 |r|
Structure:
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