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Target
RNA-directed RNA polymerase
Ligand
BDBM50150385
Substrate
n/a
Meas. Tech.
ChEMBL_305746 (CHEMBL829418)
IC50
490±n/a nM
Citation
 Gopalsamy, A; Lim, K; Ellingboe, JW; Krishnamurthy, G; Orlowski, M; Feld, B; van Zeijl, M; Howe, AY Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett 14:4221-4 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
NS5B protein | Hepatitis C virus NS5B RNA-dependent RNA polymerase
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50150385
Synonyms:
2-[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-amino]-pentanedioic acid | CHEMBL184500
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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