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Target
Flavin reductase (NADPH)
Ligand
BDBM50061625
Substrate
n/a
Meas. Tech.
ChEMBL_2153628 (CHEMBL5038175)
Kd
1380±n/a nM
Citation
 Kim, M; Ha, JH; Choi, J; Kim, BR; Gapsys, V; Lee, KO; Jee, JG; Chakrabarti, KS; de Groot, BL; Griesinger, C; Ryu, KS; Lee, D Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX? Reductase B as a Novel Thrombocytopenia Therapeutic Target. J Med Chem 65:2548-2557 (2022) [PubMed]  Article 
Target
Name:
Flavin reductase (NADPH)
Synonyms:
1.3.1.24 | 1.5.1.30 | BLVRB | BLVRB_HUMAN | BVR-B | Biliverdin reductase B | Biliverdin-IX beta-reductase | FLR
Type:
PROTEIN
Mol. Mass.:
22123.63
Organism:
Homo sapiens
Description:
ChEMBL_100283
Residue:
206
Sequence:
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ
  
Inhibitor
Name:
BDBM50061625
Synonyms:
4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid | Am 80 | CHEMBL25202 | Tamibarotene | US11744839, Compound of formula 3 | US9963439, AM80 | retinobenzoic acid
Type:
Small organic molecule
Emp. Form.:
C22H25NO3
Mol. Mass.:
351.4388
SMILES:
CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12
Structure:
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