Reaction Details Report a problem with these data
Target
Flavin reductase (NADPH)
Ligand
BDBM50582214
Substrate
n/a
Meas. Tech.
ChEMBL_2153628 (CHEMBL5038175)
Kd
200±n/a nM
Citation
 Kim, M; Ha, JH; Choi, J; Kim, BR; Gapsys, V; Lee, KO; Jee, JG; Chakrabarti, KS; de Groot, BL; Griesinger, C; Ryu, KS; Lee, D Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX? Reductase B as a Novel Thrombocytopenia Therapeutic Target. J Med Chem 65:2548-2557 (2022) [PubMed]  Article 
Target
Name:
Flavin reductase (NADPH)
Synonyms:
1.3.1.24 | 1.5.1.30 | BLVRB | BLVRB_HUMAN | BVR-B | Biliverdin reductase B | Biliverdin-IX beta-reductase | FLR
Type:
PROTEIN
Mol. Mass.:
22123.63
Organism:
Homo sapiens
Description:
ChEMBL_100283
Residue:
206
Sequence:
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ
  
Inhibitor
Name:
BDBM50582214
Synonyms:
ATALUREN | Ataluren | PTC-124 | PTC124 | Translarna | US11744839, Compound of formula 4
Type:
Small organic molecule
Emp. Form.:
C15H9FN2O3
Mol. Mass.:
284.242
SMILES:
OC(=O)c1cccc(c1)-c1noc(n1)-c1ccccc1F
Structure:
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