Target
Cyclic GMP-AMP synthase
Ligand
BDBM50582670
Substrate
n/a
Meas. Tech.
ChEMBL_2155362 (CHEMBL5040022)
IC50
9200±n/a nM
Citation
 Tan, JWu, BChen, TFan, CZhao, JXiong, CFeng, CXiao, RDing, CTang, WZhang, A Synthesis and Pharmacological Evaluation of Tetrahydro-?-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J Med Chem 64:7667-7690 (2021) [PubMed]  Article 
Target
Name:
Cyclic GMP-AMP synthase
Synonyms:
2'3'-cGAMP synthase | 2.7.7.86 | CGAS_MOUSE | Cgas | Mab-21 domain-containing protein 1 | Mb21d1 | Synonyms=Mb21d1 | cGAMP synthase | m-cGAS
Type:
PROTEIN
Mol. Mass.:
58224.36
Organism:
Mus musculus
Description:
ChEMBL_119133
Residue:
507
Sequence:
MEDPRRRTTAPRAKKPSAKRAPTQPSRTRAHAESCGPQRGARSRRAERDGDTTEKPRAPGPRVHPARATELTKDAQPSAMDAAGATARPAVRVPQQQAILDPELPAVREPQPPADPEARKVVRGPSHRRGARSTGQPRAPRGSRKEPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
  
Inhibitor
Name:
BDBM50582670
Synonyms:
CHEMBL5092651
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O3
Mol. Mass.:
501.365
SMILES:
Cc1cc(CC(=O)NCC(=O)N2CCc3[nH]c4c(Cl)c(Cl)cc(-c5ccn(C)n5)c4c3C2)no1
Structure:
Search PDB for entries with ligand similarity: