Reaction Details Report a problem with these data
Target
Phosphatidylinositol 4-kinase beta
Ligand
BDBM50582730
Substrate
n/a
Meas. Tech.
ChEMBL_2155471 (CHEMBL5040131)
Kd
850±n/a nM
Citation
 Williamson, DS; Smith, GP; Mikkelsen, GK; Jensen, T; Acheson-Dossang, P; Badolo, L; Bedford, ST; Chell, V; Chen, IJ; Dokurno, P; Hentzer, M; Newland, S; Ray, SC; Shaw, T; Surgenor, AE; Terry, L; Wang, Y; Christensen, KV Design and Synthesis of Pyrrolo[2,3- J Med Chem 64:10312-10332 (2021) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase beta
Synonyms:
PI4-kinase beta subunit | Phosphatidylinositol 4-kinase, PI4K | PI4K-beta | PI4Kbeta | PtdIns 4-kinase beta | NPIK | PI4K92 | PIK4B | PI4KB_HUMAN | PI4KB | PIK4CB | Phosphatidylinositol 4-kinase beta
Type:
Protein
Mol. Mass.:
91373.30
Organism:
Human
Description:
n/a
Residue:
816
Sequence:
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
  
Inhibitor
Name:
BDBM50582730
Synonyms:
CHEMBL5087055
Type:
Small organic molecule
Emp. Form.:
C21H27N9O
Mol. Mass.:
421.51
SMILES:
Cc1c(cnn1[C@@H]2CCOC2)Nc3nc(c4c(c(n(c4n3)C)N5CCC[C@H]5C)C#N)N
Structure:
Search PDB for entries with ligand similarity: