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Target
Lanosterol 14-alpha demethylase
Ligand
BDBM50582909
Substrate
n/a
Meas. Tech.
ChEMBL_2156246 (CHEMBL5040906)
IC50
209±n/a nM
Citation
 Liu, W; Sun, Z; An, Y; Liu, Y; Fan, H; Han, J; Sun, B Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure. Eur J Med Chem 228:0 (2022) [PubMed]  Article 
Target
Name:
Lanosterol 14-alpha demethylase
Synonyms:
1.14.14.154 | CP51_CANAL | CYP51 | CYPLI | Cytochrome P450 51 | Cytochrome P450-14DM | Cytochrome P450-LIA1 | ERG11 | ERG16 | ERG16 | Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase
Type:
PROTEIN
Mol. Mass.:
60679.24
Organism:
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Description:
ChEMBL_58
Residue:
528
Sequence:
MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF
  
Inhibitor
Name:
BDBM50582909
Synonyms:
CHEMBL5088292
Type:
Small organic molecule
Emp. Form.:
C23H20N4O
Mol. Mass.:
368.4311
SMILES:
O=C(NC(Cn1cncn1)c1ccccc1)\C=C\c1cccc2ccccc12
Structure:
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