Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Ligand
BDBM50583752
Substrate
n/a
Meas. Tech.
ChEMBL_2158058 (CHEMBL5042808)
IC50
6.0±n/a nM
Citation
 Weber, CSipos, MPaczal, ABalint, BKun, VFoloppe, NDokurno, PMassey, AJWalmsley, DLHubbard, REMurray, JBenwell, KEdmonds, TDemarles, DBruno, ABurbridge, MCruzalegui, FKotschy, A Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem 64:6745-6764 (2021) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Synonyms:
DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2
Type:
PROTEIN
Mol. Mass.:
66690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508025
Residue:
601
Sequence:
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
  
Inhibitor
Name:
BDBM50583752
Synonyms:
CHEMBL5073976
Type:
Small organic molecule
Emp. Form.:
C18H18N6O
Mol. Mass.:
334.3751
SMILES:
Cc1nc2ccc(nc2n1CCc1ccco1)-c1cc(N)nc(N)c1
Structure:
Search PDB for entries with ligand similarity: