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Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50153209
Substrate
n/a
Meas. Tech.
ChEMBL_306823 (CHEMBL623666)
IC50
>100000±n/a nM
Citation
 Receveur, JM; Bjurling, E; Ulven, T; Little, PB; Nørregaard, PK; Högberg, T 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists. Bioorg Med Chem Lett 14:5075-80 (2004) [PubMed]  Article  BDB Entry
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50153209
Synonyms:
CHEMBL365055 | N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide
Type:
Small organic molecule
Emp. Form.:
C22H27F3N4O4
Mol. Mass.:
468.4694
SMILES:
CCN(CC)CCNC(=O)c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1OC
Structure:
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