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Target
Nuclear receptor subfamily 2 group E member 1
Ligand
BDBM50584387
Substrate
n/a
Meas. Tech.
ChEMBL_2159731 (CHEMBL5044481)
EC50
3000±n/a nM
Citation
 Faudone, G; Zhubi, R; Celik, F; Knapp, S; Chaikuad, A; Heering, J; Merk, D Design of a Potent TLX Agonist by Rational Fragment Fusion. J Med Chem 65:2288-2296 (2022) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 2 group E member 1
Synonyms:
NR2E1 | NR2E1_HUMAN | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll
Type:
PROTEIN
Mol. Mass.:
42606.25
Organism:
Homo sapiens
Description:
ChEMBL_104473
Residue:
385
Sequence:
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
  
Inhibitor
Name:
BDBM50584387
Synonyms:
CHEMBL5088898
Type:
Small organic molecule
Emp. Form.:
C19H16ClF3N4O2
Mol. Mass.:
424.804
SMILES:
COc1cc(N)c(Cl)cc1C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1
Structure:
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