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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50585046
Substrate
n/a
Meas. Tech.
ChEMBL_2161409 (CHEMBL5046159)
IC50
690±n/a nM
Citation
 Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett 13:577-585 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
Serum/glucocorticoid-regulated kinase 1 (SGK1) | Serine/threonine-protein kinase Sgk1 | Serum/glucocorticoid regulated kinase | Serine/threonine-protein kinase Sgk1 (SGK) | SGK1_HUMAN | SGK1 | SGK
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Human
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50585046
Synonyms:
CHEMBL5086263
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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