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Target
Pantetheinase
Ligand
BDBM480973
Substrate
n/a
Meas. Tech.
ChEMBL_2162817 (CHEMBL5047678)
IC50
10±n/a nM
Citation
 Casimiro-Garcia, A; Allais, C; Brennan, A; Choi, C; Dower, G; Farley, KA; Fleming, M; Flick, A; Frisbie, RK; Hall, J; Hepworth, D; Jones, H; Knafels, JD; Kortum, S; Lovering, FE; Mathias, JP; Mohan, S; Morgan, PM; Parng, C; Parris, K; Pullen, N; Schlerman, F; Stansfield, J; Strohbach, JW; Vajdos, FF; Vincent, F; Wang, H; Wang, X; Webster, R; Wright, SW Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem 65:757-784 (2022) [PubMed]  Article 
Target
Name:
Pantetheinase
Synonyms:
3.5.1.92 | Pantetheine hydrolase | VNN1_MOUSE | Vanin-1 | Vascular non-inflammatory molecule 1 | Vnn1
Type:
PROTEIN
Mol. Mass.:
57084.66
Organism:
Mus musculus
Description:
ChEMBL_120311
Residue:
512
Sequence:
MGMSWWLACAAAFSALCVLKASSLDTFLAAVYEHAVILPKDTLLPVSHSEALALMNQNLDLLEGAIVSAAKQGAHIIVTPEDGIYGVRFTRDTIYPYLEEIPDPQVNWIPCDNPKRFGSTPVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSQGKLVARYHKQNIFMGEDQFNVPMEPEFVTFDTPFGKFGVFTCFDILFHDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAWAMGMGVNFLAANLHNPSRRMTGSGIYAPDSPRVFHYDRKTQEGKLLFAQLKSHPIHSPVNWTSYASSVESTPTKTQEFQSIVFFDEFTFVELKGIKGNYTVCQNDLCCHLSYQMSEKRADEVYAFGAFDGLHTVEGQYYLQICILLKCKTTNLRTCGSSVDTAFTRFEMFSLSGTFGTRYVFPEVLLSEVKLAPGEFQVSSDGRLVSLKPTSGPVLTIGLFGRLYGKDWASNASSDFIAHSLIIMLIVTPIIHYLC
  
Inhibitor
Name:
BDBM480973
Synonyms:
US10906888, Example 190
Type:
Small organic molecule
Emp. Form.:
C17H20N6O
Mol. Mass.:
324.3803
SMILES:
O=C(N1CCCCC1)c1cnc(NC2(CC2)c2cncnc2)nc1
Structure:
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