Target
Histone deacetylase 8
Ligand
BDBM50585748
Substrate
n/a
Meas. Tech.
ChEMBL_2163768 (CHEMBL5048629)
IC50
11000±n/a nM
Citation
 Belayet, JBBeamish, SRahaman, MAlanani, SVirdi, RSFrick, DNRahman, AFMTUlicki, JSBiswas, SArnold, LARoni, MSRCheng, EYSteeber, DAFrick, KMHossain, MM Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice. J Med Chem 65:3388-3403 (2022) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50585748
Synonyms:
CHEMBL5086240
Type:
Small organic molecule
Emp. Form.:
C22H38O6S2
Mol. Mass.:
462.664
SMILES:
CC(C)(C)OC(=O)CC(O)\C=C\CCSSCC\C=C\C(O)CC(=O)OC(C)(C)C
Structure:
Search PDB for entries with ligand similarity: