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Target
Cyclin-dependent kinase 5
Ligand
BDBM50155225
Substrate
n/a
Meas. Tech.
ChEMBL_306160 (CHEMBL832348)
IC50
25±n/a nM
Citation
 Helal, CJ; Sanner, MA; Cooper, CB; Gant, T; Adam, M; Lucas, JC; Kang, Z; Kupchinsky, S; Ahlijanian, MK; Tate, B; Menniti, FS; Kelly, K; Peterson, M Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Bioorg Med Chem Lett 14:5521-5 (2004) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50155225
Synonyms:
CHEMBL365855 | N-(5-Cyclobutyl-thiazol-2-yl)-2-phenyl-acetamide | N-(5-cyclobutylthiazol-2-yl)-2-phenylacetamide
Type:
Small organic molecule
Emp. Form.:
C15H16N2OS
Mol. Mass.:
272.365
SMILES:
O=C(Cc1ccccc1)Nc1ncc(s1)C1CCC1
Structure:
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