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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM12581
Substrate
n/a
Meas. Tech.
ChEMBL_2264047
IC50
500±n/a nM
Citation
 Gendaszewska-Darmach, E; Garstka, MA; Błażewska, KM Targeting Small GTPases and Their Prenylation in Diabetes Mellitus. J Med Chem 64:9677-9710 (2021) [PubMed] 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Farnesyl pyrophosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthetase | Dimethylallyltranstransferase | Geranyltranstransferase | Farnesyl diphosphate synthase (FPPS) | FPP synthetase | FPP synthase | P14324 | FPPS_HUMAN | FDPS | FPS | KIAA1293 | Farnesyl diphosphate synthase
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Human
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM12581
Synonyms:
JMC515594 Compound 62 | (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid | CHEMBL834 | Bisphosphonate 6
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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