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Target
Beclin-1
Ligand
BDBM50586574
Substrate
n/a
Meas. Tech.
ChEMBL_2169048 (CHEMBL5054107)
Kd
2200±n/a nM
Citation
 Yang, Q; Qiu, X; Zhang, X; Yu, Y; Li, N; Wei, X; Feng, G; Li, Y; Zhao, Y; Wang, R Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells. J Med Chem 64:13475-13486 (2021) [PubMed]  Article 
Target
Name:
Beclin-1
Synonyms:
BECN1 | BECN1_HUMAN | Beclin-1-C 35 kDa | Beclin-1-C 37 kDa | Coiled-coil myosin-like BCL2-interacting protein | GT197 | Protein GT197
Type:
PROTEIN
Mol. Mass.:
51874.54
Organism:
Human
Description:
ChEMBL_118255
Residue:
450
Sequence:
MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
  
Inhibitor
Name:
BDBM50586574
Synonyms:
CHEMBL5093197
Type:
Small organic molecule
Emp. Form.:
C153H277N63O34S
Mol. Mass.:
3575.303
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCCCCC\C=C\CCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r,t:160|
Structure:
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