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Target
Amyloid-beta precursor protein
Ligand
BDBM116257
Substrate
n/a
Meas. Tech.
ChEMBL_2169653 (CHEMBL5054712)
IC50
3.0±n/a nM
Citation
 Machauer, R; Lueoend, R; Hurth, K; Veenstra, SJ; Rueeger, H; Voegtle, M; Tintelnot-Blomley, M; Rondeau, JM; Jacobson, LH; Laue, G; Beltz, K; Neumann, U Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease. J Med Chem 64:15262-15279 (2021) [PubMed]  Article 
Target
Name:
Amyloid-beta precursor protein
Synonyms:
A4_HUMAN | APP | A4 | AD1 | Cerebral vascular amyloid peptide | Amyloid intracellular domain 59 | P3(42) | PN-II | AICD-50 | PreA4 | Amyloid intracellular domain 57 | S-APP-alpha | P3(40) | Amyloid beta Protein | Gamma Secretase | S-APP-beta | Soluble APP-beta | Alzheimer disease amyloid protein | Gamma-CTF(59) | Gamma-CTF(57) | Protease nexin-II | Amyloid intracellular domain 50 | Beta amyloid A4 protein | C31 | AID(59) | Gamma-CTF(50) | C99 | AID(57) | Amyloid beta A4 protein | Gamma-secretase C-terminal fragment 50 | Amyloid beta protein (sAPPbeta) | Beta-amyloid protein 42 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | Beta-amyloid protein 40 | Soluble APP-alpha | AICD-57 | Gamma-secretase | Amyloid -protein (A 42) | Amyloid protein (Abeta42b) | Beta-APP42 | APPI | Beta-APP40 | Amyloid beta protein Abeta(1-42) | beta-Amyloid Precursor Protein (APP) | AID(50) | CVAP | AICD-59 | ABPP | C83
Type:
Single-pass type I membrane protein
Mol. Mass.:
86890.41
Organism:
Human
Description:
P05067
Residue:
770
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM116257
Synonyms:
US8637508, 34 | US10035794, Example 34 | US10683287, Example 34
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@]1(CO[C@@](C(=N1)N)(C)C(F)(F)F)c2c(ccc(n2)NC(=O)c3c(cc(cn3)C(F)(F)F)Cl)F
Structure:
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