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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM119812
Substrate
n/a
Meas. Tech.
ChEMBL_2170368 (CHEMBL5055427)
IC50
44±n/a nM
Citation
 Li, C; Yang, X; Luo, Y; Liu, H; Zhong, X; Zhou, X; Zeng, T; Tao, L; Zhou, Y; Gou, K; Yang, X; Liu, X; Chen, Q; Zhao, Y; Luo, Y Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment. J Med Chem 64:18175-18192 (2021) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Human
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM119812
Synonyms:
US20240034730, Compound ASLAN003 | US8691852, 20
Type:
Small organic molecule
Emp. Form.:
C19H14F2N2O3
Mol. Mass.:
356.3229
SMILES:
COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1
Structure:
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