Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50213614
Substrate
n/a
Meas. Tech.
ChEMBL_2186073 (CHEMBL5098155)
EC50
40±n/a nM
Citation
 Navarro, G; Gonzalez, A; Sánchez-Morales, A; Casajuana-Martin, N; Gómez-Ventura, M; Cordomí, A; Busqué, F; Alibés, R; Pardo, L; Franco, R Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB J Med Chem 64:9354-9364 (2021) [PubMed] 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Human
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50213614
Synonyms:
(6aR,10aR)-6,6,9-trimethyl-3-(2-methylpentan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | CHEMBL252536
Type:
Small organic molecule
Emp. Form.:
C22H32O2
Mol. Mass.:
328.4883
SMILES:
CCCC(C)(C)c1cc(O)c2[C@@H]3CC(C)=CC[C@H]3C(C)(C)Oc2c1 |c:14|
Structure:
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