Target
Transthyretin
Ligand
BDBM50197883
Substrate
n/a
Meas. Tech.
ChEMBL_2187564 (CHEMBL5099646)
Kd
9.9±n/a nM
Citation
 Pinheiro, FPallarès, IPeccati, FSánchez-Morales, AVarejão, NBezerra, FOrtega-Alarcon, DGonzalez, DOsorio, MNavarro, SVelázquez-Campoy, AAlmeida, MRReverter, DBusqué, FAlibés, RSodupe, MVentura, S Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J Med Chem 65:14673-14691 (2022) [PubMed] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Human
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50197883
Synonyms:
CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Compound Tafamidis | US20240150297, Compound Tafamadis | Vyndaqel
Type:
Small organic molecule
Emp. Form.:
C14H7Cl2NO3
Mol. Mass.:
308.116
SMILES:
OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
Structure:
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