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Target
Substance-K receptor
Ligand
BDBM50159870
Substrate
n/a
Meas. Tech.
ChEMBL_303375 (CHEMBL839693)
Ki
>3000±n/a nM
Citation
 D'Andrea, P; Porcelloni, M; Madami, A; Patacchini, R; Altamura, M; Fattori, D Generation of a new class of hNK(2) receptor ligands using the 'fragment approach'. Bioorg Med Chem Lett 15:585-8 (2005) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM50159870
Synonyms:
(R)-2-[3-Methyl-3-(4-phenoxy-phenyl)-ureido]-N-(3-morpholin-4-yl-propyl)-3-phenyl-propionamide | CHEMBL180238
Type:
Small organic molecule
Emp. Form.:
C30H36N4O4
Mol. Mass.:
516.6312
SMILES:
CN(C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccc(Oc2ccccc2)cc1
Structure:
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