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Target
Cytochrome P450 2C19
Ligand
BDBM31772
Substrate
n/a
Meas. Tech.
ChEMBL_2188374 (CHEMBL5100456)
IC50
0.020000±n/a nM
Citation
 Fallot, LB; Suresh, RR; Fisher, CL; Salmaso, V; O'Connor, RD; Kaufman, N; Gao, ZG; Auchampach, JA; Jacobson, KA Structure-Activity Studies of 1 J Med Chem 65:15238-15262 (2022) [PubMed] 
Target
Name:
Cytochrome P450 2C19
Synonyms:
(S)-limonene 6-monooxygenase | Cytochrome P450-11A | P450-254C | Mephenytoin 4-hydroxylase | (S)-limonene 7-monooxygenase | Cytochrome P450 2C19 (CYP2C19) | CYP2C19 | CYPIIC17 | (R)-limonene 6-monooxygenase | CYPIIC19 | Fenbendazole monooxygenase (4'-hydroxylating) | CP2CJ_HUMAN | Cytochrome P450 2C19 [I331V] | Cytochrome P450-254C | P450-11A
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Human
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM31772
Synonyms:
Brentan | 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid | cid_4189 | Dactarin | CHEMBL91 | Miconazole | US9138393, Miconazole Nitrate | US9144538, Miconazole Nitrate
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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