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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50161466
Substrate
n/a
Meas. Tech.
ChEMBL_302160 (CHEMBL829228)
Kd
119±n/a nM
KOFF
0.14 s-1
KON
1180000 M-1s-1
Citation
 Shi, ZD; Karki, RG; Oishi, S; Worthy, KM; Bindu, LK; Dharmawardana, PG; Nicklaus, MC; Bottaro, DP; Fisher, RJ; Burke, TR Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic. Bioorg Med Chem Lett 15:1385-8 (2005) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
Grb2-SH2 | GRB2 adapter protein | Growth factor receptor-bound protein 2 | GRB2_HUMAN | GRB2 | ASH
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Human
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50161466
Synonyms:
(R)-N-(1-{(S)-2-Carbamoyl-1-[2-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-ethylcarbamoyl]-ethylcarbamoyl}-cyclohexyl)-3-(4-phosphonomethyl-benzyl)-succinamic acid | CHEMBL362853
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
NC(=O)CC(NC(=O)C1(CCCCC1)NC(=O)C(CC(O)=O)Cc1ccc(C[P+](O)(O)[O-])cc1)C(=O)NCCNc1ccc([N+]([O-])=O)c2n[o+][n-]c12
Structure:
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