Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50151343
Substrate
n/a
Meas. Tech.
ChEMBL_303574 (CHEMBL828974)
Ki
1200±n/a nM
Citation
 Grunewald, GLRomero, FACriscione, KR Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. J Med Chem 48:1806-12 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50151343
Synonyms:
(+)-3-(fluoromethyl)-7-(thiomorpholinosulfonyl)-1,2,3,4-tetrahydroisoquinoline | 3-Fluoromethyl-7-(thiomorpholine-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline | CHEMBL355581
Type:
Small organic molecule
Emp. Form.:
C14H19FN2O2S2
Mol. Mass.:
330.441
SMILES:
FCC1Cc2ccc(cc2CN1)S(=O)(=O)N1CCSCC1
Structure:
Search PDB for entries with ligand similarity: