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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM50591187
Substrate
n/a
Meas. Tech.
ChEMBL_2199524 (CHEMBL5112040)
EC50
>1000±n/a nM
Citation
 Xu, F; Zhang, X; Chen, Z; He, S; Guo, J; Yu, L; Wang, Y; Hou, C; Ai-Furas, H; Zheng, Z; Smaill, JB; Patterson, AV; Zhang, ZM; Chen, L; Ren, X; Ding, K Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells. J Med Chem 65:14032-14048 (2022) [PubMed] 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
Serine/threonine-protein kinase AKT | RAC-PK-beta | Protein kinase Akt-2 | Protein kinase B beta (AKT2) | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | Protein kinase B, beta | PKB beta | Protein kinase B (Akt 2) | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase Rac alpha/beta | Serine/threonine-protein kinase AKT2 | AKT2_HUMAN | AKT2
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Human
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM50591187
Synonyms:
CHEMBL5197756
Type:
Small organic molecule
Emp. Form.:
C53H72N8O4
Mol. Mass.:
885.21
SMILES:
COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3ccc(NC(=O)C4CC4)cc3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:56:57:54.55.60:61,THB:58:57:54:60.59.61,58:59:54:62.57.56,56:55:61:62.57.58|
Structure:
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