Target
C-C chemokine receptor type 3
Ligand
BDBM50163636
Substrate
n/a
Meas. Tech.
ChEMBL_306838 (CHEMBL831029)
IC50
0.007000±n/a nM
Citation
 De Lucca, GVKim, UTVargo, BJDuncia, JVSantella, JBGardner, DSZheng, CLiauw, AWang, ZEmmett, GWacker, DAWelch, PKCovington, MStowell, NCWadman, EADas, AMDavies, PYeleswaram, SGraden, DMSolomon, KANewton, RCTrainor, GLDecicco, CPKo, SS Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem 48:2194-211 (2005) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
CCR3_RAT | Ccr3 | Cmkbr3
Type:
PROTEIN
Mol. Mass.:
41648.91
Organism:
Rattus norvegicus
Description:
ChEMBL_1445730
Residue:
359
Sequence:
MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF
  
Inhibitor
Name:
BDBM50163636
Synonyms:
1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(5-acetyl-4-methylthiazol-2-yl)urea | 1-(5-Acetyl-4-methyl-thiazol-2-yl)-3-{(1R,2S)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-urea | CHEMBL195433
Type:
Small organic molecule
Emp. Form.:
C26H35FN4O2S
Mol. Mass.:
486.645
SMILES:
CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C
Structure:
Search PDB for entries with ligand similarity: