Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50164250
Substrate
n/a
Meas. Tech.
ChEMBL_302592 (CHEMBL839552)
Ki
>3000±n/a nM
Citation
 McBriar, MDGuzik, HXu, RParuchova, JLi, SPalani, AClader, JWGreenlee, WJHawes, BEKowalski, TJO'Neill, KSpar, BWeig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem 48:2274-7 (2005) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
  
Inhibitor
Name:
BDBM50164250
Synonyms:
1-[4-(3-Cyano-phenyl)-cyclohexyl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea | CHEMBL366161
Type:
Small organic molecule
Emp. Form.:
C27H30F4N4O2
Mol. Mass.:
518.5463
SMILES:
O[C@@H]1CCN(CCN([C@H]2CC[C@H](CC2)c2cccc(c2)C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)C1 |wU:11.14,8.7,1.0,(7.96,-8.41,;7.19,-7.05,;7.82,-5.67,;6.68,-4.63,;5.34,-5.4,;4.01,-4.63,;4.01,-3.08,;2.67,-2.31,;1.33,-3.09,;1.33,-4.63,;,-5.4,;-1.35,-4.63,;-1.35,-3.09,;,-2.32,;-2.68,-5.4,;-4.01,-4.63,;-5.34,-5.4,;-5.34,-6.94,;-4.01,-7.71,;-2.68,-6.94,;-4.01,-9.25,;-4.01,-10.79,;2.67,-.75,;1.34,.02,;4,.02,;4,1.56,;2.67,2.33,;2.67,3.89,;4,4.64,;4,6.18,;5.34,3.89,;5.34,2.33,;6.68,4.66,;8.03,5.45,;7.47,3.31,;5.9,6.01,;5.67,-6.91,)|
Structure:
Search PDB for entries with ligand similarity: