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Target
Stimulator of interferon genes protein
Ligand
BDBM453551
Substrate
n/a
Meas. Tech.
ChEMBL_2203820 (CHEMBL5116528)
EC50
8300±n/a nM
Citation
 Niu, J; Bai, H; Li, Z; Gao, Y; Zhang, Y; Wang, X; Yang, Y; Xu, Y; Geng, M; Xie, Z; Zhou, B Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
Mediator of IRF3 activation | Transmembrane protein 173 | Endoplasmic reticulum interferon stimulator | Synonyms=ERIS | hSTING | hMITA | STING_HUMAN | STING1 | ERIS | MITA | STING | TMEM173
Type:
Protein
Mol. Mass.:
42215.19
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM453551
Synonyms:
4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4- oxobutanoic acid | US10730849, Example 16
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc2cc(sc2cc1OC)C(=O)CCC(=O)O
Structure:
Search PDB for entries with ligand similarity: