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Target
Delta-type opioid receptor
Ligand
BDBM50087820
Substrate
n/a
Meas. Tech.
ChEMBL_2207676 (CHEMBL5120384)
EC50
190546072±n/a nM
Citation
 Deo, O; Alvi, S; Pham, V; Christopoulos, A; Thal, DM; Jörg, M; Capuano, B; Valant, C; Scammells, PJ The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ J Med Chem 65:12367-12385 (2022) [PubMed] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRK1 | opioid receptor, delta 1 | OPRD_HUMAN | OPRD1 | OPRD
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Human
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50087820
Synonyms:
CHEMBL3426797
Type:
Small organic molecule
Emp. Form.:
C30H31BrO4
Mol. Mass.:
534.14
SMILES:
CC1(C)CC(=O)C2=C(C1)OC1=C(C2c2ccc(OCc3ccccc3Br)cc2)C(=O)CC(C)(C)C1 |c:6,11|
Structure:
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