Reaction Details Report a problem with these data
Target
Ribosomal protein S6 kinase beta-2
Ligand
BDBM50168247
Substrate
n/a
Meas. Tech.
ChEMBL_306115 (CHEMBL830066)
IC50
40±n/a nM
Citation
 Székelyhidi, Z; Pató, J; Wáczek, F; Bánhegyi, P; Hegymegi-Barakonyi, B; Erös, D; Mészáros, G; Hollósy, F; Hafenbradl, D; Obert, S; Klebl, B; Kéri, G; Orfi, L Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Bioorg Med Chem Lett 15:3241-6 (2005) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase beta-2
Synonyms:
KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B
Type:
PROTEIN
Mol. Mass.:
53460.10
Organism:
Human
Description:
ChEMBL_306115
Residue:
482
Sequence:
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
  
Inhibitor
Name:
BDBM50168247
Synonyms:
2,3-Di-thiophen-2-yl-benzo[g]quinoxaline-7-carboxylic acid | CHEMBL426445
Type:
Small organic molecule
Emp. Form.:
C21H12N2O2S2
Mol. Mass.:
388.462
SMILES:
OC(=O)c1ccc2cc3nc(-c4cccs4)c(nc3cc2c1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: