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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50168316
Substrate
n/a
Meas. Tech.
ChEMBL_302139 (CHEMBL841763)
Kd
67±n/a nM
Citation
 Kang, SU; Shi, ZD; Worthy, KM; Bindu, LK; Dharmawardana, PG; Choyke, SJ; Bottaro, DP; Fisher, RJ; Burke, TR Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform. J Med Chem 48:3945-8 (2005) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50168316
Synonyms:
CHEMBL263328 | N-{4-[(7S,14R,18S)-18-Carbamoylmethyl-9-carboxymethyl-14-(5-methyl-indol-1-ylmethyl)-17,20-dioxo-8-(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-10-yl]-phenyl}-oxalamic acid
Type:
Small organic molecule
Emp. Form.:
C39H46N6O9
Mol. Mass.:
742.8173
SMILES:
Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C3)c3ccc(NC(=O)C(O)=O)cc3)ccc2c1 |t:36|
Structure:
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