Reaction Details Report a problem with these data
Target
Nuclear factor of activated T-cells, cytoplasmic 1
Ligand
BDBM50595362
Substrate
n/a
Meas. Tech.
ChEMBL_2216480 (CHEMBL5129612)
IC50
4500±n/a nM
Citation
 Sánchez-Morales, A; Biçer, A; Panagiotopoulos, V; Crecente-Garcia, S; Benaiges, C; Bayod, S; Luís Hernández, J; Busqué, F; Matsoukas, MT; Pérez-Riba, M; Alibés, R Design and synthesis of a novel non peptide CN-NFATc signaling inhibitor for tumor suppression in triple negative breast cancer. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 1
Synonyms:
NF-ATc | NF-ATc1 | NFAC1_HUMAN | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | Nuclear factor of activated T-cells cytoplasmic 1 | Nuclear factor of activated T-cells, cytoplasmic 1
Type:
PROTEIN
Mol. Mass.:
101251.15
Organism:
Human
Description:
ChEMBL_11335
Residue:
943
Sequence:
MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSPPPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQGLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGVASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
  
Inhibitor
Name:
BDBM50595362
Synonyms:
CHEMBL5174163
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2N3O4S2
Mol. Mass.:
498.403
SMILES:
Cc1ccc(s1)C(=O)NCC(=O)Nc1cc(ccc1Cl)S(=O)(=O)Nc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: