Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 3
Ligand
BDBM50170859
Substrate
n/a
Meas. Tech.
ChEMBL_312537 (CHEMBL832580)
IC50
301±n/a nM
Citation
 Durgam, GG; Virag, T; Walker, MD; Tsukahara, R; Yasuda, S; Liliom, K; van Meeteren, LA; Moolenaar, WH; Wilke, N; Siess, W; Tigyi, G; Miller, DD Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. J Med Chem 48:4919-30 (2005) [PubMed]  Article 
Target
Name:
Lysophosphatidic acid receptor 3
Synonyms:
EDG7 | LPA3 | LPAR3 | LPAR3_HUMAN | Lysophosphatidic acid receptor 1/3 | Lysophosphatidic acid receptor 3 (LPAR3) | Lysophosphatidic acid receptor Edg-7
Type:
Enzyme
Mol. Mass.:
40149.72
Organism:
Homo sapiens (Human)
Description:
Q9UBY5
Residue:
353
Sequence:
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
  
Inhibitor
Name:
BDBM50170859
Synonyms:
3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl)-3-methylisoxazol-5-yl)benzylthio)propanoic acid | 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methylisoxazol-5-yl)benzylthio)propanoic acid | 3-(4-{4-[1-(2-Chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-benzylsulfanyl)-propionic acid | CHEMBL361501
Type:
Small organic molecule
Emp. Form.:
C23H23ClN2O5S
Mol. Mass.:
474.957
SMILES:
CC(OC(=O)Nc1c(C)noc1-c1ccc(CSCCC(O)=O)cc1)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: