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Target
Plasmepsin X
Ligand
BDBM50595796
Substrate
n/a
Meas. Tech.
ChEMBL_2218027 (CHEMBL5131159)
IC50
0.400000±n/a nM
Citation
 de Lera Ruiz, M; Favuzza, P; Guo, Z; Zhao, L; Hu, B; Lei, Z; Zhan, D; Murgolo, N; Boyce, CW; Vavrek, M; Thompson, J; Ngo, A; Jarman, KE; Robbins, J; Boddey, J; Sleebs, BE; Lowes, KN; Cowman, AF; Olsen, DB; McCauley, JA The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria. ACS Med Chem Lett 13:1745-1754 (2022) [PubMed] 
Target
Name:
Plasmepsin X
Synonyms:
PLM10_PLAF7 | PMX | 3.4.23.- | PfPMX | Plasmepsin 10
Type:
PROTEIN
Mol. Mass.:
65102.67
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_119140
Residue:
573
Sequence:
MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSHVIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEEINKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSDNENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPLKHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRRSFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISFEGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGDIYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHSTACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLLGSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
  
Inhibitor
Name:
BDBM50595796
Synonyms:
CHEMBL5199100
Type:
Small organic molecule
Emp. Form.:
C28H34N4O4
Mol. Mass.:
490.60
SMILES:
CCC1(CC)CC(=O)N([C@@H]2CCOc3ccc(cc23)C(=O)N[C@@H]2c3ccccc3OC2(C)C)C(=N)N1 |r|
Structure:
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