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Target
Dual specificity mitogen-activated protein kinase kinase 1/2
Ligand
BDBM50355497
Substrate
n/a
Meas. Tech.
ChEMBL_2218638 (CHEMBL5131972)
IC50
14±n/a nM
Citation
 García-Cárceles, J; Caballero, E; Gil, C; Martínez, A Kinase Inhibitors as Underexplored Antiviral Agents. J Med Chem 65:935-954 (2022) [PubMed] 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1/2
Synonyms:
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | p-MEK1/2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 795758
Components:
This complex has 2 components.
Component 1
Name:
Dual specificity mitogen-activated protein kinase kinase 2
Synonyms:
MAP kinase kinase 2 | MAPK/ERK kinase 2 | MAPKK 2 | Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | ERK activator kinase 2 | MP2K2_HUMAN | MAP2K2 | MEK2 | MKK2 | PRKMK2 | VHL-MAP2K1/MAP2K2 | Dual specificity mitogen-activated protein kinase kinase; MEK1/2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44423.61
Organism:
Human
Description:
gi_13489054
Residue:
400
Sequence:
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
  
Component 2
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
ERK activator kinase 1 | Mitogen-activated protein kinase 1 (MEK1) | MAPK/ERK kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | MEK-1 | MAP kinase kinase 1 | MAPK/ERK kinase 1 | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | MP2K1_HUMAN | MAP2K1 | MEK1 | PRKMK1 | VHL-MAP2K1/MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase
Type:
Other Protein Type
Mol. Mass.:
43439.03
Organism:
Human
Description:
Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates.
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
  
Inhibitor
Name:
BDBM50355497
Synonyms:
AZD-6244 | CHEMBL1614701
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: