Target
Thyroid hormone receptor beta
Ligand
BDBM50171800
Substrate
n/a
Meas. Tech.
ChEMBL_321321 (CHEMBL882591)
IC50
9±n/a nM
Citation
 Hangeland, JJFriends, TJDoweyko, AMMellström, KSandberg, JGrynfarb, MRyono, DE A new class of high affinity thyromimetics containing a phenyl-naphthylene core. Bioorg Med Chem Lett 15:4579-84 (2005) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50171800
Synonyms:
CHEMBL371245 | [4-(3-Bromo-4-hydroxy-phenoxy)-3,5-dichloro-phenyl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C14H9BrCl2O4
Mol. Mass.:
392.029
SMILES:
OC(=O)Cc1cc(Cl)c(Oc2ccc(O)c(Br)c2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: