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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM28759
Substrate
n/a
Meas. Tech.
ChEMBL_304256 (CHEMBL829727)
EC50
0.2±n/a nM
Citation
 Pinelli, A; Godio, C; Laghezza, A; Mitro, N; Fracchiolla, G; Tortorella, V; Lavecchia, A; Novellino, E; Fruchart, JC; Staels, B; Crestani, M; Loiodice, F Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. J Med Chem 48:5509-19 (2005) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Ppara | Nr1c1 | Ppar | Peroxisome Proliferator-Activated Receptor alpha
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mouse
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM28759
Synonyms:
CHEMBL191275 | (2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid | LT175 (S-1)
Type:
Small organic molecule
Emp. Form.:
C21H18O3
Mol. Mass.:
318.13
SMILES:
OC(=O)[C@H](Cc1ccccc1)Oc1ccc(cc1)-c1ccccc1 |r|
Structure:
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