Target
Reverse transcriptase/RNaseH
Ligand
BDBM50172753
Substrate
n/a
Meas. Tech.
ChEMBL_321416 (CHEMBL881947)
IC50
32100±n/a nM
Citation
 Bedoya, LMBeltrán, MSancho, ROlmedo, DASánchez-Palomino, Sdel Olmo, ELópez-Pérez, JLMuñoz, ESan Feliciano, AAlcamí, J 4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett 15:4447-50 (2005) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50172753
Synonyms:
5-Hydroxy-6-isobutyryl-8,8-dimethyl-4-phenyl-8H-pyrano[2,3-f]chromen-2-one | CHEMBL198546 | mammea A/ADcyclo D | mesuagin
Type:
Small organic molecule
Emp. Form.:
C24H22O5
Mol. Mass.:
390.4285
SMILES:
CC(C)C(=O)c1c(O)c2c(cc(=O)oc2c2C=CC(C)(C)Oc12)-c1ccccc1 |c:17|
Structure:
Search PDB for entries with ligand similarity: