Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50597191
Substrate
n/a
Meas. Tech.
ChEMBL_2223062 (CHEMBL5136396)
EC50
16±n/a nM
Citation
 Suchankova, A; Stampelou, M; Koutsouki, K; Pousias, A; Dhingra, L; Barkan, K; Pouli, N; Marakos, P; Tenta, R; Kolocouris, A; Lougiakis, N; Ladds, G Discovery of a High Affinity Adenosine A ACS Med Chem Lett 13:923-934 (2022) [PubMed] 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | Adenosine A3 receptor (A3AR) | AA3R_HUMAN | ADORA3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Human
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50597191
Synonyms:
CHEMBL5195631
Type:
Small organic molecule
Emp. Form.:
C19H17N5
Mol. Mass.:
315.38
SMILES:
Cn1nc(-c2ccccc2)c2cnnc(NCc3ccccc3)c12
Structure:
Search PDB for entries with ligand similarity: