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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50597430
Substrate
n/a
Meas. Tech.
ChEMBL_2223428 (CHEMBL5136762)
IC50
>30000±n/a nM
Citation
 Hill, MD; Blanco, MJ; Salituro, FG; Bai, Z; Beckley, JT; Ackley, MA; Dai, J; Doherty, JJ; Harrison, BL; Hoffmann, EC; Kazdoba, TM; Lanzetta, D; Lewis, M; Quirk, MC; Robichaud, AJ SAGE-718: A First-in-Class  J Med Chem 65:9063-9075 (2022) [PubMed] 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HPCN1 | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | HK2 | KCNA5_HUMAN | KCNA5 | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Human
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50597430
Synonyms:
Dalzanemdor | DALZANEMDOR
Type:
Small organic molecule
Emp. Form.:
C27H43F3O2
Mol. Mass.:
456.63
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@](C)(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC[C@](C)(O)C(F)(F)F |r,t:9|
Structure:
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