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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM80642
Substrate
n/a
Meas. Tech.
ChEMBL_2223583 (CHEMBL5136917)
IC50
109±n/a nM
Citation
 Bavo, F; Pallavicini, M; Pucci, S; Appiani, R; Giraudo, A; Eaton, B; Lucero, L; Gotti, C; Moretti, M; Whiteaker, P; Bolchi, C From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue. J Med Chem 65:10079-10097 (2022) [PubMed] 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_CHICK | CHRNA7
Type:
PROTEIN
Mol. Mass.:
56940.23
Organism:
Chicken
Description:
ChEMBL_120662
Residue:
502
Sequence:
MGLRALMLWLLAAAGLVRESLQGEFQRKLYKELLKNYNPLERPVANDSQPLTVYFTLSLMQIMDVDEKNQVLTTNIWLQMYWTDHYLQWNVSEYPGVKNVRFPDGLIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGGWSLDLQMQEADISGYISNGEWDLVGIPGKRTESFYECCKEPYPDITFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLSSMEMNTVSGQQCSNGNMLYIGFRGLDGVHCTPTTDSGVICGRMTCSPTEEENLLHSGHPSEGDPDLAKILEEVRYIANRFRDQDEEEAICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM80642
Synonyms:
CHEMBL191491 | cid_6433339 | MG 624 | MLS002172460 | SMR001254093 | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]azanium;iodide | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]ammonium;iodide | triethyl-[2-[4-[(E)-styryl]phenoxy]ethyl]ammonium;iodide
Type:
Small organic molecule
Emp. Form.:
C22H30NO+
Mol. Mass.:
324.23
SMILES:
CC[N+](CC)(CC)CCOc1ccc(\C=C\c2ccccc2)cc1
Structure:
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