Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 4 group A member 2
Ligand
BDBM50101853
Substrate
n/a
Meas. Tech.
ChEMBL_2227567 (CHEMBL5141080)
EC50
3000±n/a nM
Citation
 Willems, S; Merk, D Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. J Med Chem 65:9548-9563 (2022) [PubMed] 
Target
Name:
Nuclear receptor subfamily 4 group A member 2
Synonyms:
NR4A2_RAT | Nr4a2 | Hzf-3 | Nurr1 | Rnr1 | NUR-related factor 1 | Nuclear orphan receptor HZF-3 | Orphan nuclear receptor NURR1 | RNR-1 | Regenerating liver nuclear receptor 1 | SL-322
Type:
PROTEIN
Mol. Mass.:
66635.79
Organism:
Rat
Description:
ChEMBL_119028
Residue:
598
Sequence:
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSRPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
  
Inhibitor
Name:
BDBM50101853
Synonyms:
(13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid | prostaglandin E1 | (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid | 11alpha,15alpha-dihydroxy-9-oxo-13-trans-prostenoic acid | PGE-1 | PGE1 | CHEMBL495 | ALPROSTADIL
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: